Table S1 - Exceptionally Long CDR3H Are Not Isotype Restricted in Bovine Immunoglobulins

Genomic annotation of the bovine immunoglobulin heavy-chain locus. For a functional gene (F), the complete coding sequence, octamer motif, TATA box, splicing signals or recombination signal sequences (RSS), and poly A motif were identified. Putative functional genes ((F)) lacked some of the described parts due to end of the contig or N’s introduced into gaps for example. ORFs are classified by alterations in the splicing signals, RSS or regulatory elements. The extension (ORF) describes fully functional genes in putative orphons. Pseudogenes (Ψ) revealed stop codons, frameshifts or mutations within the RSS, which lead to abolition of recombination. Fragmented loci were also defined as Ψ [38], [39], [40], [41]. (XLS)