A trial to compare efficacy and tolerability of Plenvu and Picoprep as cleansing agents of the large bowel before colonoscopy (examination ofthe bowel with a fiberoptic device)

Primary objectives: Aim of the study is to compare the efficacy and tolerability of the relatively new bowel preparation Plenvu with the well established bowel preparation Picoprep as cleansing agents before colonoscopy. This is to test whether the low volume Polyethylin Glycol-electrolytes lavage solution preparation Plenvu would have non-inferior efficacy on bowel preparation compared with Picosulfate based Picoprep with a better effect on compliance and tolerability.
Primary endpoints: The primary endpoint is the efficacy of cleansing preparations measured by the quality of cleansing. This is done using the validated Harfield Cleansing Scale. The cleansing quality is measured after dividing the colon into 5 segments (Rectum, sigmoid colon, Descending colon, Transverse colon, and Ascending colon/Cecum) and each segment is scored from 0 (irremovable heavy hard stool) to 4 (empty and clean), then a total grade is given. Grade A (all segments scored 3 or 4) and B (one or more segments scored 2) are considered as successful cleansing. Grade C (one or more segments scored 1) and D (one or more segments scored 0) is considered unsuccessful cleansing8.