The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female mice

To compare gene expression between the materal X (Xm) and paternal X (Xp), we used a flurorescence-based cell sorting to separate the maternal X from the paternal X. Then we performed gene expression analysis using data obtained from RNA-seq of young Xm and Xp cells To compare gene expression between the materal X (Xm) and paternal X (Xp) in neurons from both young and old mice, we used a flurorescence-based cell sorting to separate the maternal X from the paternal X. Then we performed gene expression analysis using data obtained from RNA-seq of young and old Xm and Xp neurons. Comparative gene expression profiling analysis for young Xm and Xp cells. Each experimental group has 5 biological replicates Comparative gene expression profiling analysis for young and old Xm and Xp cells. Each experimental group has 5 biological replicates