Design, Preparation, and Implementation of an Imidazole-Based Chiral Biaryl P,N-Ligand for Asymmetric Catalysis

A new
strategy for increasing the barrier to rotation in biaryls
has been developed that allows for the incorporation of 5-membered
aromatic heterocycles into chiral atropisomers. Using this concept,
an imidazole-based biaryl P,N-ligand has been designed and prepared
as a single enantiomer. This ligand performs exceptionally well in
the enantioselective A3-coupling, demonstrating the potential
of this new design element.