Clinical, pathological and molecular features of patients with mismatch repair deficiency.

1MSI-H and/or loss of expression of MMR proteins by immunohistochemistry.2MSS and normal expression of MMR proteins by immunohistochemistry.3Including first and second degree relatives; Lynch syndrome-associated neoplasia includes: endometrium, stomach, ovaries, urinary tract, small intestine, pancreas, bile ducts, brain or sebaceous glands.4Signet ring cells and/or Crohn’s-like lymphocytic reaction and/or tumor infiltrating lymphocytes and/or medullary growth pattern and/or anaplastic tumor.