Myocardial proteome from obese rats with cardiac dysfunction C4PR_LIV

Obesity is a complex metabolic disease considered a global pandemic and associated with high incidence of cardiovascular disease. The excess of adipose tissue may promotes maladaptation that result in alterations in structure and function of the heart; however, the mechanisms are not fully elucidated. Proteomics may provide a deeper understanding into the pathophysiological process and contribute to the identification of new potential therapeutic targets. Thus, the aim of this was evaluate the myocardial protein expression in healthy and obese rats induced by Western diet to better comprehend the network of mechanisms inherent to cardiac dysfunction in obesity. For this purpose, we performed proteomic approaches based on nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) followed by label-free quantification.