Crystal structure of human TRF1 TRFH domain in complex with compound 1

Crystal structure of human TRF1 TRFH domain in complex with compound 1 Descriptor: 1,2-ETHANEDIOL, N-cyclopropylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Telomeric repeat-binding factor 1 Authors: Casale, G, Le Bihan, Y.-V, Van Montfort, R.L.M, Guettler, S. Deposit date: 2024-11-12 Release date: 2025-11-19 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening. Sci Rep, 15, 2025