ReMEA paper Supplementary data by Higgins et al.

## Usage Notes
- Data is provided under the CC BY-NC, which permits reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
- Please cite this dataset using the Figshare DOI if used in any publications or derivative work.
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## Contents
Supplementary data 1 Cell line ReMEA scores
Supplementary data 2 Fold changes for the LSD1i proteomics
Supplementary data 3 ReMEA scores for the LSD1i proteomics
Supplementary data 4 Average ReMEA scores for primary AML cells
Supplementary data 5 Fold changes from chemotherapy phospho
Supplementary data 6 ReMEA score for chemotherapy phospho
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## Description
This dataset contains supporting data for the publication titled "Response Marker Enrichment Analysis (ReMEA) predicts the antiproliferative impact of pharmacological and genetic perturbagens on cancer cells" submitted to Nucleic Acids Research. The data include the collection of ReMEA scores computed with the four large cell line proteomics datasets referenced in the paper. Scores were made using the cell line signatures whose construction is described in the publication.

All files are provided in [format(s), e.g., CSV, TXT, PDF, .R, .py, .zip].
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## File Inventory
Below is a description of each of the 9 files included dataset 1:
1. **[STAT_matched_DRUG_scores.csv]**
Description: Single Train And Test Set scores for drug perturbations. Signatures made from and tested with same proteomics dataset.

2. **[STAT_matched_RNAi_scores.csv]**
Description: Single Train And Test Set scores for RNAi perturbations. Signatures made from and tested with same proteomics dataset.

3. **[STAT_matched_CRISPR_scores.csv]**
Description: Single Train And Test Set scores for CRISPR perturbations. Signatures made from and tested with same proteomics dataset.

4. **[LODO_AVG_DRUG_scores.csv]**
Description: Leave One Dataset Out scores for drug perturbations.

5. **[LODO_AVG_RNAi_scores.csv]**
Description: Leave One Dataset Out scores for RNAi perturbations.

6. **[LODO_AVG_CRISPR_scores.csv]**
Description: Leave One Dataset Out scores for CRISPR perturbations.

7. **[k_fold_goncalves_DRUG_remea_scores.csv]**
Description: K-fold ReMEA drug scores using the Goncalves et al. 2022 proteomics dataset as described in publication.

8. **[k_fold_goncalves_RNAi_remea_scores.csv]**
Description: K-fold ReMEA RNAi scores using the Goncalves et al. 2022 proteomics dataset as described in publication.

9. **[k_fold_goncalves_CRISPR_remea_scores.csv]**
Description: K-fold ReMEA CRISPR scores using the Goncalves et al. 2022 proteomics dataset as described in publication.
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