Undifferentiated human embryonic stem cells (hESCs) were treated with WNT and FGF agonists for three days to generate NMP-like axial progenitors (NMPs). Overall design: Triplicate samples of undiffere
RNA sequencing was performed to investigate the potential crosstalk between TINCR and microRNAs. Overall design: microRNA profiles of T47D with TINCR knockdown and scramble were generated by deep sequ
FBXW7 is and E3 ubiquitin ligase and is highly mutated in colorectal cancer. We used human colon organoids with engineered FBXW7 hotspot mutations to investigate novel targets of E3 ligase activity wi
The RAS pathway is frequently exploited by cancer cells to sustain their proliferation and survival. ERK is the most distal kinase in the RAS signaling cascade, playing a pivotal role in signaling out
