Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #65
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Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #65 Descriptor: (7M)-7-[(4S)-imidazo[1,2-b]pyridazin-3-yl]-1-[(1R)-1-phenylethyl]-3-(piperazin-1-yl)pyrido[3,4-b]pyrazin-2(1H)-one, 1,2-ETHANEDIOL, MAP/microtubule affinity-regulating kinase 3 Authors: Delker, S.L, Abendroth, J. Deposit date: 2023-10-19 Release date: 2024-10-23 Last modified: 2025-06-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J.Med.Chem., 67, 2024
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2023-10-19
