Increasing the chemical potential of the germ-line antibody repertoire.
收藏PubMed Central1993-05-01 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC46435/
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资源简介：
To augment the chemical potential of the immunological repertoire, a metal ion-binding light chain has been introduced into the murine genome. Mice containing the transgene were subsequently immunized with a fluorescein conjugate. The transgenic light chain was found at a high frequency in the anti-fluorescein memory B-cell compartment. This general method should be applicable to other cofactors and small molecules and should lead to generation of antibodies with unique catalytic activities. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-05-01
