Impact of comorbidities on preferences for outcome and process attributes of biologicals.

(A) Participants with psoriatic arthritis attached higher value to probability of ACR 20 response and sustainability but less importance to time until response. (B) Respondents with cardiovascular disease prioritized avoidance of mild and severe AE as well as ACR 20 response. Time until response, treatment location, frequency and delivery method were less relevant for them than for other participants. (C) Participants with diabetes were particularly interested in short treatment duration. (D) Those with arterial hypertension attached special importance to a low risk of mild AE and a short treatment duration. Differences in RIS were tested for significance with one-way ANOVA or Brown-Forsythe tests. Bars: Means with standard deviations. AE: adverse events; art.: arterial; CV disease: cardiovascular disease; RIS: Relative Importance Scores. * p≤0.05, ** p≤0.01.