Frequencies of V<sub>H</sub> replacement footprint motifs with different length in the N1 and N2 regions of the mouse IgH genes.
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aUnique sequences were identified after removal of IgH sequences with identical CDR3 regions. bTotal number of IgH gene sequences with clearly identifiable VH, DH, and JH genes. cN1 region refers to the V-D junction. dN2 region refers to the D-J junction. eThe frequencies of potential VH replacement footprint motifs in the N1 and N2 regions were compared by two-tailed Chi-square with Yate’s correction. p<0.05 was considered significant and p<0.0001is considered extremely significant. fNumbers of IgH gene sequences with VH replacement “footprint” motifs in the N1 regions were divided by the total number of IgH gene sequences with V, D, J gene assignment. gMouse IgH gene sequences were previously described. hThe mouse IgH gene sequences were downloaded from the NCBI database on May 7, 2011. The GI numbers of these sequences were included in Table S1.
