Summary of transcriptome data and experimental comparisons that comprise the analyses reported in the following sections.

Experiments were chosen that utilise zebrafish or mouse as the model organism, and discrete datasets are defined by the mutated gene-of-interest. Differential gene expression testing was performed for each comparison, with the threshold for significance set to a false discovery rate (FDR)-adjusted p-value of less than 0.05. The total number of differentially expressed genes (Total DEGs) is listed for each comparison, as well as the number that were chromosomally colocalised with the mutated gene (CC-DEGs). The significance column (Sig.) indicates the Bonferroni-adjusted p-values for over-representation of CC-DEGs (Fisher’s Exact Test, ***: < 0.001, **: < 0.01, *: < 0.05).