Eremophilane-Type Sesquiterpene Derivatives from the Roots of <i>Ligularia lapathifolia</i>
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Six new highly oxygenated eremophilane-type sesquiterpene derivatives (1−6), including a norbisesquiterpene, were isolated from an extract of the roots of Ligularia lapathifolia, and their structures were elucidated by spectroscopic methods. The structure of 1 was confirmed by single-crystal X-ray crystallography. In addition, the cytotoxicity of compounds 1, 2, 3, 5, and 6 was evaluated against selected cancer cell lines, including human stomach carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines.
创建时间:
2007-02-23



