Activated TRAF6 synthesizes unanchored polyubiquitin chains
收藏reactome.org2025-01-16 收录
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Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates free K63 -linked polyubiquitin chains that non-covalently associate with ubiquitin receptors of TAB2/TAB3 regulatory proteins of the TAK1 complex, leading to the activation of the TAK1 kinase.
多泛素化TRAF6（作为E3泛素连接酶）生成游离的K63连接多泛素链，这些链非共价地与TAK1复合物中TAB2/TAB3调控蛋白的泛素受体相结合，从而激活TAK1激酶。
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