A SWI/SNF-dependent transcriptional repression mediated by POU2AF2/C11orf53 at enhancer.

Recent studies have identified a previously uncharacterized protein C11orf53 (now named POU2AF2/OCA-T1), functions as a new co-activator of POU2F3, the master transcription factor which is critical for both normal and neoplastic tuft cell identity and viability. Here, we demonstrated that POU2AF2 functions as an “Yin-Yang” factor which mediates both transcriptional activation and repression at distal enhance elements. The proteomics study aims to identify potential interactors with POU2AF2 in different cell lines which may enable us to further understand the function of POU2AF2 in human cancer.