ACE activity and risk of acquiring young-onset hypertension among people with different genotypes.

*The estimates and standard error (SE) of ACE activity, the odds ratio (OR) and the 95% confidence interval (CI) of young-onset hypertension were performed individually for each SNP by generalized estimating equations; adjusted for age, gender, and drugs; and controlled for intra-family correlation.†Young-onset hypertension was treated as a binary trait, and was regressed on genotypes constructed from measured genotyped tag-SNPs using a generalized linear model with a logit link function, adjusting age, gender, and anti-hypertensive medications.