A novel kinase inhibitor for b-catenin mutant hepatocellular carcinoma [Cut&Run]. A novel kinase inhibitor for b-catenin mutant hepatocellular carcinoma [Cut&Run]
收藏NIAID Data Ecosystem2026-03-14 收录
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We screened HCC organoids to identify a CTNNB1-mutant HCC selective small molecule (WNTinib), with MOA depending on reactivation of cytoplasmic EZH2, leading to its nuclear translocation and selective transcriptional block of WNT targets Overall design: Comparative Cut and Run analysis of H3K27me3-binding sites for MYC-CTNNB1 organoids +/- WNTinib vs MYC-Tp53 organoids +/- WNTinib, at 2 timepoints (+DMSO)
创建时间：
2022-09-16
