Mmp7

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

本基因编码的蛋白质属于基质金属蛋白酶家族，该家族成员参与细胞外基质的降解，并在组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭等过程中发挥作用。编码的前体蛋白经过蛋白酶解加工，生成成熟的、锌依赖性内肽酶酶。缺乏该编码蛋白的小鼠在功能上的cryptdins存在缺陷。此基因定位于第9号染色体上其他基质金属蛋白酶基因的簇中。[由RefSeq提供，2016年2月]