Gut microbiome in the Norwegian Lundehund

The Norwegian Lundehund dog is a highly inbred breed with an effective population size of 13 individuals. The Lundehund has a high rate of a protein-losing enteropathy in the small intestine that is often reported as Lundehund syndrome, which negatively affects longevity and life-quality. An outcrossing project with the Buhund, Norrbottenspets and Icelandic sheepdog was recently established to reintroduce genetic diversity to the Lundehund and improve its health. To assess whether there was an association between host genetic diversity and the microbiome composition, we sampled the fecal microbiomes of 75 dogs of the parental (Lundehund), F1 (Lundehund x Buhund), and F2 (F1 x Lundehund) generations. The results of our study are published at the following link https://www.frontiersin.org/articles/10.3389/fmicb.2023.1209158/fullThe dataset includes the raw sequences obtained by amplifying the V3-V4 region of the 16S rRNA gene with bacterial 16S rRNA primers of two blank samples (containing only the buffer solution) and 90 dog stool samples. The suffix B indicates a cross with Buhund, the suffix I indicates a cross with Icelandic sheepdog and the suffix N indicates a cross with Norrbottenspets.