Crystal structure of calcium-dependent protein kinase 1 (CDPK1) from Cryptosporidium parvum in complex with inhibitor WIN-1-159.

Crystal structure of calcium-dependent protein kinase 1 (CDPK1) from Cryptosporidium parvum in complex with inhibitor WIN-1-159. Descriptor: (6M)-6-(2-chloro-4-methoxyphenyl)-8-methyl-2-[3-(piperazine-1-sulfonyl)anilino]pyrido[2,3-d]pyrimidin-7(8H)-one, CALCIUM ION, Calmodulin-domain protein kinase 1 Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2025-03-19 Release date: 2026-04-01 Last modified: 2026-05-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-guided design of calcium-dependent protein kinase 1 (CDPK1) inhibitors for cryptosporidiosis. J.Infect.Dis., 2026