Adverse events n (%).

a Total events: total patients with at least one adverse event;
b Other neuropsychiatric symptoms included language disorders, ataxia, hearing decrease, impairments of calculation and irritability;
c Other skin symptoms included hypohidrosis and decrustation;
d Gastrointestinal reactions included vomiting, nausea, and abdominal discomfort;
e Cytopenia included leucopoenia, oligocythemia, and thrombocytopenia;
f Other events included fever, lower limbs edema, tinnitus, renal dysfunction, palpitation, ostealgia/arthralgia, hyperdacryosis, upper respiratory infection, oral ulcer, chest stufly and bitter taste.
Adverse events n (%).