Adverse events n (%).

a Total events: total patients with at least one adverse event; b Other neuropsychiatric symptoms included language disorders, ataxia, hearing decrease, impairments of calculation and irritability; c Other skin symptoms included hypohidrosis and decrustation; d Gastrointestinal reactions included vomiting, nausea, and abdominal discomfort; e Cytopenia included leucopoenia, oligocythemia, and thrombocytopenia; f Other events included fever, lower limbs edema, tinnitus, renal dysfunction, palpitation, ostealgia/arthralgia, hyperdacryosis, upper respiratory infection, oral ulcer, chest stufly and bitter taste. Adverse events n (%).