A Novel platform for single-cell RNA-sequencing and its application in genome medicine [bulk]. A Novel platform for single-cell RNA-sequencing and its application in genome medicine [bulk]

we describe the utility of this novel platform in the field of genome medicine using a full-length approach to evaluate the relationship between transcriptional and mutational heterogeneity on single cells in dermal fibroblasts derived from patients with Hutchinson-Gilford progeria syndrome (HGPS) Overall design: Bulk RNA sequencing in order to detrmnie the dynamic range of the assay