Genome-wide profiling of histone H1 variants in T47D-MTVL cells

Human somatic cells may contain up to seven members of the histone H1 family contributing to chromatin compaction and regulation of nuclear processes, apparently with certain subtype specificities. Previous studies in T47D breast cancer cells determined that H1 variants are distributed in a variant-specific manner throughout the genome, although only H1.2 and H1X endogenous variants were mapped. Now, we performed ChIP-seq of five endogenous H1 variants (H1.0, H1.2, H1.4, H1.5, H1X) in T47D cells. Genomic distribution of H1.0, H1.2, H1.4, H1.5, and H1X linker histones in T4LD-MTVL cells (ChIP-seq)