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High-resolution fitness profiling of residue 105 in class A beta-lactamases

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NIAID Data Ecosystem2026-05-02 收录
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Site-saturation mutagenesis of residue 105 was performed for five representative class A beta-lactamases. The resulting libraries were screened against a number of beta-lactam antibiotic/inhibitor combinations, and the fitness of each variant was determined with high-throughput seequencing.

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2025-05-25
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