Significant Expansion of the Solid State Landscape of Salicylic Acid Based on Charge-Assisted Hydrogen Bonding Interactions

Successful
cocrystallization between a salicylate salt with salicylic
acid and chemically distinct carboxylic acids suggests the robustness
of the carboxylic acid-carboxylate supramolecular synthon. This type
of robust synthon involving charge-assisted hydrogen bonding interactions
has the potential to significantly expand the solid-state landscape
of ionizable molecules.