Uba1
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This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
本基因编码泛素激活E1家族的一员。编码的蛋白启动泛素激活和转移级联反应，催化泛素共价结合至细胞蛋白的初始步骤，以标记其进行蛋白酶体降解。泛素激活酶利用ATP在酶的保守催化半胱氨酸与泛素的C端羧酸盐之间形成硫酯键。选择性剪接导致多种转录本变体。[由RefSeq提供，2013年1月]
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