Characterization of morphological alterations in micropapillary adenocarcinoma of the lung. Characterization of morphological alterations in micropapillary adenocarcinoma of the lung

Micropapillary adenocarcinoma of the lung is a cancer with poor prognosis and characterized by the presence of tumor cells with ring-like glandular structure floating within alveolar spaces. We investigated the association between its morphological, biochemical, and immunohistochemical characteristics and malignancy using the KU-Lu-MPPt3 cell line established from a patient with micropapillary adenocarcinoma. Two subpopulations of KU-Lu-MPPt3 cells, adhesive (AD) and clumpy and suspended (CS) cells, were prepared and subjected to DNA microarray. Overall design: Microarray analysis was performed to investigate the changes in gene expression due to morphological differences in KU-Lu-MPPt3 adhesive (AD) cells and KU-Lu-MPPt3 clumpy and suspended (CS) cells established from the micropapillary adenocarcinoma of the lung. In addition, PC9 which is lung adenocarcinoma cell line was added to the sample.