官方服务：
资源简介：
Cas9-dependent off-target assessments of Td-CBEs
应用场景：
创建时间：
2022-05-06
相关数据集
High-fidelity base editing mediated by Cpf1-cytidine deaminase fusion. High-fidelity base editing mediated by Cpf1-cytidine deaminase fusion
C-to-T base editing mediated by CRISPR/Cas9 base editors (BEs) needs a G/C-rich PAM and the editing fidelity is compromised by unwanted indels and non-C-to-T substitutions. We developed CRISPR/Cpf1-ba
NIAID Data Ecosystem80
A Dual-Deaminase CRISPR Base Editor Enables Concurrent Adenine and Cytosine Editing
Adenine and cytosine base editors enable programmable modification of A-to-G and C-to-T DNA edits, respectively. However, existing editors can induce only a single type of modification, thereby limiti
NIAID Data Ecosystem50
CRISPR base editing of cis-regulatory elements enables target gene perturbations. CRISPR base editing of cis-regulatory elements enables target gene perturbations
CRISPR technology has demonstrated broad utility for controlling target gene expression. However, there remains a need for strategies capable of modulating expression via the precise editing of non-co
NIAID Data Ecosystem40
Additional file 5 of What is the available evidence for the range of applications of genome-editing as a new tool for plant trait modification and the potential occurrence of associated off-target effects: a systematic map
Additional file 5. List of relevant studies and the systematic map database to answer secondary question 1.
NIAID Data Ecosystem80
A temperature-tolerant CRISPR base editor mediates highly efficient and precise gene inactivation in vivo
CRISPR nucleases generate a broad spectrum of mutations that includes undesired editing outcomes which attenuate phenotypes and complicate experimental analysis and interpretation. Here, we develop an
NIAID Data Ecosystem50
