COVID-19 ACTIV-4 ACUTE: A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic Strategies in Hospitalized Adults with COVID-19 (ACTIV4A)

This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic strategies for prevention of adverse outcomes in COVID-19 positive inpatients.]]>
Inclusion Criteria In order to be eligible to participate in this study, an individual must meet all of the following criteria: ≥ 18 years of age Hospitalized for COVID-19* Enrolled within 72 hours of hospital admittance or 72 hours of positive COVID test Expected to require hospitalization for > 72 hours (See arm-specific Appendices for additional criteria and details) *It is strongly recommended to confirm SARS-CoV-2 with a positive microbiological test prior to randomization. At centers where there is delay in confirming the diagnosis, a sufficiently high clinical suspicion is sufficient to proceed with randomization as long as confirmation is expected within 24 hours. Exclusion Criteria Imminent death Requirement for chronic mechanical ventilation via tracheostomy prior to hospitalization Pregnancy See arm-specific appendices ]]>