Odds ratios of exacerbation of chronic obstructive pulmonary disease with a 5°C decrease in mean temperature# stratified by age, sex, vaccination and inhaled medicine.

#Adjusted for relative humidity, barometric pressure, wind speed, and duration of sunshine.*Received inhaled medicine, including inhaled long-acting ß2 agonist, long-acting muscarinic antagonist or/and inhaled corticosteroid for more than 28 days within 6 months before the index day.+Received vaccination within one year before the event.