Gastric adenocarcinoma of fundic gland type vs matched normal mucosa. Gastric adenocarcinoma of fundic gland type vs matched normal mucosa

Background: Gastric adenocarcinoma of fundic gland type (GA-FG) is rare, and the mechanisms of carcinogenesis and growth progression have not to be elucidated. Results: Transcriptional profiles of 3 fresh-frozen GA-FG and surrounding normal mucosa were compared. Key features of gene expression analysis suggested that TTF-1/NKX2-1 acts as an important transcription factor in GA-FG. This study will provide insight into the mechanism of development. All samples were obtained prior to resection of target lesions in order to minimize effects of cauterization. Overall design: Biopsy samples from GA-FG and matched normal mucosa were endoscopically obtained from each patients using endoscopic biopsy forceps. The tissues were collected prospectively with informed consent and the approval of the institutional review board.