3,4-Dihydroxypyrrolidines via Modified Tandem Aza-Payne/Hydroamination Pathway
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https://figshare.com/articles/dataset/3_4_Dihydroxypyrrolidines_via_Modified_Tandem_Aza_Payne_Hydroamination_Pathway/2503498
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The outcome of a tandem aza-Payne/hydroamination reaction is modified via the use of a latent nucleophile. The latter initially serves as an electrophile to intercept the aziridine alkoxide and afterward turns into a nucleophile thereby performing the aziridine ring opening, out competing the intramolecular aza-Payne pathway. Subsequent hydroamination in the same pot provides N-Ts enamide carbonates, which can be easily converted into biologically significant 3,4-dihydroxylactams.
创建时间：
2016-02-20
