Neuropsychological and behavioral data of PLS patients.

Scores are corrected for age, gender and education. P = differences between patient groups; values refer to the Mann-Whitney U-test. WCST, global score calculation = [N used cards-(completed categories*10)], higher scores mean worse performances [23]. Fluency indices calculation = for each letter (P, F, L) or category (animals, fruits, cars) a partial index was calculated in order to correct for motor disabilities as following: [(60-seconds for reading words previously reported in 1’)/N words previously reported in 1’]; the total semantic or phonemic index was obtained by averaging the 3 semantic or phonemic partial indices, respectively. Higher scores mean worse performances [21]. Abbreviations: BADA = “Batteria per l'Analisi del Deficit Afasico”; co = cut-off; FBI = frontal behavioral battery; HDRS = Hamilton depression rating scale; PLS-cd = primary lateral sclerosis with cognitive deficits; PLS-cu = cognitively unimpaired primary lateral sclerosis; WCST = Wisconsin card sorting test.