PTEN regulates chromatin accessibility and hematopoietic lineage plasticity via the transcription factor PU.1. PTEN regulates chromatin accessibility and hematopoietic lineage plasticity via the transcription factor PU.1

We elucidate the molecular and cellular mechanism underlying PTEN-regulated hematopoietic lineage choice and suggest a critical role of PU.1 in modulating the epigenetic state of prepro-B progenitors. Overall design: Examination of chromatin accessibility in stem and progenitor cells from WT and PTEN loss mouse bone marrow. Examination of chromatin accessibility and expression level in prepro-B cells from WT and PTEN loss mouse bone marrow.