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An Aza-Prins Cyclization Approach to Functionalized Indolizidines from 2‑Allylpyrrolidines

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NIAID Data Ecosystem2026-03-07 收录
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The stereoselective synthesis of a diverse set of functionalized indolizidine systems has been accomplished through the aza-Prins cyclization of 2-allylpyrrolidines. The condensation of aldehydes onto 2-allylpyrrolidines yields iminium ions that undergo highly diastereoselective aza-Prins cyclization, producing up to two stereogenic centers and two new rings in one step.

创建时间:
2012-11-02
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