Impact of FGF-2 and FGF-2 containing cell culture supernatants on the intracellular protein composition of ReNcell derived neuron

FGF-2 is an important protein involved in a vast number of molecular pathways and a number of cellular functions including glial cell differentiation and response to axon injury. This protein was found to be present significantly in supernatants of female derived murine oligodendrocyte progenitor cells (OPC) that have been maintained under hyperoxic conditions. Therefore, this protein might be important in protecting the brain against oxidative stress. Functional assays on neuronal cells in the presence of FGF-2 or OPC culture supernatants were performed and findings related to the impact of the treatment conditions on the intracellular protein response of ReNcell derived neurons were reported.