Baseline muscle metabolism (no L-arginine) during rest and different exercise regimens in MELAS subjects versus healthy control subjects as measured by 31P-MRS (mean ± SD).

Key:AnPwr = anaerobic power; ATP = adenosine triphosphateATPAn = ATP anaerobic; ATPOx = ATP oxidative; ATPtot = ATP totalHEP = high energy phosphates; [Mg2+] = intracellular magnesiumpMg = free or paracellular magnesium and is calculated by the formula—log10[Mg2+]Pi = inorganic phosphate; Pi/PCr ratio = ADP ratioPCr = phosphocreatine; PCrRec 1/2 = halftime of phosphocreatine recovery in secondsRPM = rotations per minute; SD = standard deviationP is two-tailed P-value of unpaired t-test* statistically significant resultKruskal-Wallis one-way analysis of variance is a non-parametric method for testing whether samples originate from the same distribution and is used for comparing two or more samples that are independent and that may have different sample sizes (Pr > Chi-square)Baseline muscle metabolism (no L-arginine) during rest and different exercise regimens in MELAS subjects versus healthy control subjects as measured by 31P-MRS (mean ± SD).