Beneficial effects of probiotic Lactobacillus paraplantarum BGCG11 on pancreatic and duodenum function in diabetic rats. Beneficial effects of probiotic Lactobacillus paraplantarum BGCG11 on pancreatic and duodenum function in diabetic rats

Diabetes mellitus, as a chronic metabolic disorder significantly impacts pancreas and among other organs it affects duodenal function. Emerging evidence suggests that probiotics can exert beneficial effects on gut health and metabolism. This study investigates the impact of the probiotic strain Lactobacillus paraplantarum BGCG11 on pancreatic and duodenal function in diabetic rats. We explore the potential mechanisms underlying the probiotic's effects, focusing on general indicators of diabetes, architecture and morphology of pancreatic islets, duodenal integrity (measuring the transfer of fluid and serum zonulin level), and the modulation of gut microbiota composition. Our findings reveal the protective and regulatory roles of L. paraplantarum BGCG11 in mitigating diabetes-induced pancreatic and duodenal dysfunction regardless of it application time (pre or post treatment), highlighting its therapeutic potential in managing diabetes-related gastrointestinal complications.