Organocatalytic Enantioselective Michael/Cyclization Domino Reaction between 3‑Amideoxindoles and α,β-Unsaturated Aldehydes: One-Pot Preparation of Chiral Spirocyclic Oxindole-γ-lactams
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https://figshare.com/articles/dataset/Organocatalytic_Enantioselective_Michael_Cyclization_Domino_Reaction_between_3_Amideoxindoles_and_-Unsaturated_Aldehydes_One-Pot_Preparation_of_Chiral_Spirocyclic_Oxindole-_-lactams/4765903
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资源简介：
The
first organocatalytic enantioselective Michael/cyclization
domino reaction between 3-amideoxindoles and α,β-unsaturated
aldehydes is described. After sequential oxidation with pyridinium
chlorochromate, a direct and one-pot preparation of highly sterically
hindered spirocyclic oxindole-γ-lactams was achieved in 51–81%
yields with 75–97% ee and ≤80/20 dr.
创建时间：
2017-03-20
