Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence. Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence

We used single-cell RNA-sequencing to characterize different types of senescent cells that arise upon oxidative stress Overall design: IMR-90 fibroblasts were induced into senescence via oxidative stress. Transcriptional states of individual senescent cells were analyzed via SPLIT-seq method.