Persistent Cryptosporidium parvum infection leads to the development of tumor microenvironment in an experimental mouse model: Results of a microarray approach. Persistent Cryptosporidium parvum infection leads to the development of tumor microenvironment in an experimental mouse model: Results of a microarray approach

Cryptosporidium parvum has been reported to induce digestive adenocarcinoma in a rodent model of chronic cryptosporidiosis. In the current study, the transcriptomes of C. parvum infected ileo-caecal regions of mice developing tumours were analysed to identifie potential genes involved in development of cancer Overall design: Whole genome microarray profiling was performed on the C. parvum infected caecum tissue at days 45 and 93 post-infection. The experimental setup consisted of total 15 mice wherein each mouse was considered as an independent experiment. (4 uninfected and 3 infected mice at day 45 post-infection ; 3 uninfected and 5 infected at 93 post-infection)