Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-272
收藏Protein Data Bank Japan2025-02-19 更新2026-04-04 收录
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Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-272 Descriptor: (1R,2S,5S)-N-{(1S,2S)-1-(5-fluoro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER Authors: Bulut, H, Hayashi, H, Kuwata, N, Tsuji, K, Das, D, Tamamura, H, Mitsuya, H. Deposit date: 2023-10-06 Release date: 2023-12-13 Last modified: 2025-02-19 Method: X-RAY DIFFRACTION (1.74 Å) Cite: An orally available P1'-5-fluorinated M pro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier. Pnas Nexus, 4, 2025
创建时间：
2023-10-06
