Single cell level investigations into the correlates of protection from attenuated Mtb vaccine candidate ΔsigH. Single cell level investigations into the correlates of protection from attenuated Mtb vaccine candidate ΔsigH

Bronchoalveolar lavage (BAL) airway cells were collected from macaques and subjected to sc-RNA sequencing to determine transcriptomic changes due to vaccinations Overall design: 23 samples from three macaque groups (unvaccinated, BCG-vaccinated, and ΔsigH-vaccinated) at pre-vaccination, post-vaccination, and post-Mtb challenge time points. Each condition has 4 samples, except "unvaccinated post-Mtb challenge" has 3 samples.