Clinical findings and viremia for NHPs challenged with MARV.

aDays after MARV challenge are in parentheses. Fever is defined as a temperature more than 2.5OF over baseline or at least 1.5OF over baseline and ≥103.5OF. Moderate rash refers to petechiae coverage of more than 20% of the skin. Lymphopenia and thrombocytopenia are defined by a ≥35% drop in numbers of lymphocytes and platelets, respectively. (ALP) alkaline phosphatase, (AST) aspartate aminotransferase, (BUN) blood urea nitrogen, (GGT) gamma glutamyltransferase: 2- to 3-fold increase,→; 4- to 5-fold increase, →→; >5 fold increase, →→→.
bNo symptoms observed.
cClinical scores in bold type with day of score in parentheses. Clinical scores were recorded each day post-challenge for each animal using a scoring system based on dyspnea, depression, recumbency, and rash. A clinical score ≥9 was the criteria for euthanasia per IACUC protocol.
dDays after MARV challenge are in parentheses. Viral load for each MARV positive day is depicted as: log10 PFU/ml/qRT-PCR positive (+) or negative (−). +, ≤5 log10; ++, ≥6 log10; +++, ≥7 log10.