Macrophages and osteoclasts stem from a bipotent progenitor that lies downstream of the common macrophage/osteoclast/dendritic cell progenitor

Macrophages (MFs), osteoclasts (OCs) and dendritic cells (DCs) are closely related, but the exact steps in their lineage commitment are unclear. We here dissect B220-CD11blow/negc-Kit+c-Fms+ mouse bone marrow (BM) cells into a CD27+Flt3+ progenitor popula Overall design: Whole transcriptome analysis of CD27 low MOP and CD27 high MODP