A longitudinal assessment of the antibody response to SARS-CoV-2 infection in the New Mexican population

While many studies have assessed immune responses to SARS-CoV-2 infection, none have studied functional antibody responses before and after vaccination of exposed patients in New Mexico in the United States. Here, we evaluate antibody binding, antibody neutralization, and antibody-dependent cell-mediated cytotoxicity (ADCC) responses from convalescent patients between 2020 and 2021. Our results indicate that binding, neutralizing, and ADCC titers remained durable over an estimated 4-month period or were boosted by vaccination. Antibody binding titer stability was comparable to that of antibodies against four common viruses. Overall, these data shed light on functional antibody responses to SARS-CoV-2 in pre-alpha variant waves in New Mexico.
, , # Data from: A longitudinal assessment of the antibody response to SARS-CoV-2 infection in the New Mexican population

Dataset DOI: [10.5061/dryad.905qfttx3](10.5061/dryad.905qfttx3)

## Description of the data and file structure

These experiments were conducted to assess antibody responses (binding, functional, and neutralizing) against SARS-CoV-2 in 2020-2021 in New Mexican patients and to assess the effect of vaccination on pre-existing antibody titers. All missing values are represented as N/A.

### Files and variables

#### File: Figure_1_data.xlsx

**Description:** 

* Column A:  patient number
* Column B:  ELISA titers agaSARS-CoV-2CoV-2 from the first blood draw of unvaccinated patients
* Column C:  ELISA titers againSARS-CoV-2V-2 from the second blood draw of unvaccinated patients
* Column D:  ELISA titers agaSARS-CoV-2CoV-2 from the first blood draw of unvaccinated patients that were later vaccinated
* Column E:  ELISA titers against SARS-CoV-22 from the second blood draw of ..., We received explicit informed consent from the study participants to publish de-identified data in the public domain. The data was de-identified by blinding experimentalists from PHI and assigning a anonymized number to each patient.