Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked

NIAID Data Ecosystem50

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis [cell line]. Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis [cell line]

肿瘤分子机制

树突状细胞

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDCs). BPDCN occurs at least three times more frequently in men than women, but the reas

NIAID Data Ecosystem40

Supplementary Materials

肿瘤分子机制

甲状腺癌基因组学

Table S1: HARRIS_HYPOXIA gene set and REACTOME_AUTOPHAGY gene set; Table S2: Hypoxia phenotype score and autophagy phenotype score of each PTC sample in the TCGA-THCA dataset; Table S3: The qPCR prime

Zenodo2025-04-07 更新70

Connexin46 in the nucleus of cancer cells: a possible role as transcription modulator [ChIP-Seq]

癌症转录调控

肿瘤分子机制

Background Oncogenes drive cancer progression, but few are active exclusively in tumor cells. Connexins (Cxs), traditionally recognized as ion channel proteins, can localize to the nucleus and regula

NIAID Data Ecosystem50